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Crane JD, MacNeil LG, Tarnopolsky MA

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HUBERMAN: They're trying to block the cispeptin pathway in order to reduce some of the vasomotor and other symptoms of menopause

Nasal delivery specific concerns Nasal administration introduces considerations not present with injection

Virus protein ligands, like trimeric spike glycoprotein interact with cellular receptors, such as ACE2, and host proteases, like transmembrane protease serine 2 (TMPRSS2), participate in virus entry by proteolytically activating virus ligands (Sallenave and Guillot, 2020