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Twelve patients meeting the New York Heart Association class III/IV heart failure classification were given a 5-week infusion of GLP-1 and the results were compared to 9 patients receiving standard therapy

This post explains the framework, not a recommendation

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Comparisons With Other Diabetes Therapies Putting GLP1s in context with other antidiabetic agents offers additional insights: Thiazolidinediones (TZDs) are associated with increased fracture risk, especially in women SGLT2 inhibitors have raised concerns in some trials, particularly canagliflozin DPP-4 inhibitors appear largely neutral regarding skeletal effects Against this backdrop, GLP1s may have a neutral or possibly safer profile, though the data are not conclusive