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Jebara et al., 2005)

In experimental systems, researchers often study how these peptides influence biological pathways associated with tissue remodeling, vascular signaling, and cellular migration

Reported cell-culture systems include dermal fibroblast and keratinocyte monolayers, where the tripeptide is studied in the context of collagen and glycosaminoglycan turnover

In dermal fibroblasts, GHK-Cu reduces TNF-alpha-induced secretion of IL-6, a major positive regulator of fibrinogen synthesis and inflammatory responses

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