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510 Hyperactive ERAD and IRE1 signaling in synovial inflammation and cell survival in RA In RA, hyperactivation of the ERAD system, known as hyper-ERAD, contributes to synoviocyte proliferation and mitigates severe ER stress by promoting an anti-apoptotic response

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Thermo Fisher Scientific) diluted in PBS for 1 h at room temperature under protection from light