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This combination approach leads to an overall increase in the efficiency and utilization of small-molecule drugs, offering promising prospects for more effective and targeted therapies

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Certain mitochondrial proteins involved in the biosynthesis of iron-sulfur clusters (ISCs), such as cysteine desulfurase NFS1, ISC proteins, CISD1, and CISD2, have been shown to negatively regulate ferroptosis by reducing the availability of Fe 2+ [3235]

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doi:10.1002/1529-0131(200201)46:1 3.0.CO;2-H

Table 3 summarizes efficacy results by sex, race, age, and ethnicity