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It does not stimulate muscle protein synthesis on its own, and it does not act on androgen receptors

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Although multiple factors contribute to the development of obesity, one crucial mechanism implicated is a profound mismatch between calorie intake and expenditure

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Lancet Diabetes Endocrinol 5(4):271279 Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, Lingvay I, McGowan BM, Oral TK, Rosenstock J, Wadden TA, Wharton S, Yokote K, Kushner RF, STEP 1 Study Group (2022) Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension