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Anemia should warrant complete work up including checking red blood cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration), reticulocyte count, iron studies (serum iron, total iron binding capacity, serum ferritin), folate, and vitamin B12 concentrations

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The proposed mechanism involves direct interaction between the AEDG sequence and histones H1/3 and H1/6, modulating chromatin accessibility at specific gene loci

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