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Se han encontrado efectos ptimos en ondas delta inducidas por DSIP alrededor de 7 nmol/kg (ICV) y aproximadamente 30 nmol/kg (inyeccin intravenosa [IV]), aunque pueden observarse diferencias segn el sitio de infusin en el cerebro

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Primary endpoint results at 24 weeks: Placebo: 1.6% body weight reduction 1mg retatrutide: 8.7% 4mg: 17.3% 8mg: 22.8% 12mg: 24.2% At 48 weeks, the 12mg cohort sustained 24.2% mean weight reduction