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We further demonstrate that the high-affinity inhibitor S-4048 sterically occludes the cytoplasmic entry pathway by trapping the transporter in a cytoplasm-facing conformation

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However, that historical origin should not be interpreted as proof that all reported effects share the same mechanism or the same biological relevance

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Thymosin beta-4 activates integrin-linked kinase in endothelial cells and promotes angiogenesis

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doi: 10.1038/s41581-021-00489-1 86

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