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Based on recent studies, SGLT2 inhibitors (SGLTis) are generally considered superior to GLP-1 receptor agonists (GLP-1s) for slowing the progression of chronic kidney disease

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Metformin primarily reduces liver glucose production and improves insulin sensitivity, while GLP-1 agonists directly activate appetite-suppressing hormones in the brain

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For individuals seeking significant weight loss, evidence-based interventions such as prescription GLP-1 medications, NHS weight management programmes, or comprehensive lifestyle support offer significantly better prospects for success