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A BioSpace report noted that a new safety signal emerged from the TRIUMPH program, though details were limited in the topline data release

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Obesity Obesity may increase risk of developing arrhythmia and lead to cardiac problems in several ways: it can affect the heart indirectly , by increasing lipid levels, blood pressure, and glucose intolerance, or directly , by increasing the blood volume, which elevates cardiac output and causes thickening of the heart muscle in the left ventricle (Mathew 2008