Handelsman Y, Bloomgarden ZT, Grunberger G, Umpierrez G, Zimmerman RS, Bailey TS, et al
doi:10.1016/j.molmed.2022.11.001 58
Understanding the Distinct Mechanisms Behind MOTS-c and 5-Amino-1MQ Before designing any stacking protocol, understanding what each peptide does at the molecular level is non-negotiable
Injection burden Can mix into one syringe or use two Best for Asymmetric dosing or staggered cycling Cycle driver Compound-specific titration CJC-1295 (no DAC) Loading 100 mcg Frequency Once daily Maintenance 200-300 mcg Route SubQ Ipamorelin Loading 100 mcg Frequency Once daily Maintenance 200-300 mcg Route SubQ Weekly Schedule Example Monday CJC-1295 200 mcg + Ipamorelin 200 mcg Tuesday CJC-1295 200 mcg + Ipamorelin 200 mcg Wednesday CJC-1295 200 mcg + Ipamorelin 200 mcg Thursday CJC-1295 200 mcg + Ipamorelin 200 mcg Friday CJC-1295 200 mcg + Ipamorelin 200 mcg Saturday CJC-1295 200 mcg + Ipamorelin 200 mcg Sunday CJC-1295 200 mcg + Ipamorelin 200 mcg When mixing both peptides into a single syringe, draw each peptide separately and combine in the syringe
Patients in Komodo Healthcare Map also tended to have lower CCI and DCSI scores, on average, than those in CDM
A p-value of 60 mL/min/1.73 m
