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PLoS One 9(5):e96905
For instance, metabolic enzymes localized in the cytoplasm or mitochondria can translocate to the nucleus and modify chromatin structure by interacting with histones and DNA, thereby directly regulating gene expression
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This phosphorylation acts like a molecular off switch
Inicialmente, se comercializaron monoagonistas de GLP-1R que tuvieron como objetivo el tratamiento de la diabetes tipo2, explotando el efecto incretnico y su carcter glucosa-dependiente, a lo que se aadi la accin reductora del peso corporal y sus efectos sobre comorbilidades asociadas1,3,5
Bariatric surgery can produce powerful and durable weight loss because it changes stomach capacity, hunger signaling, fullness, and metabolism
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