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doi: 10.1111/j.1464-410X.2009.09041.x

Its actions, however, are highly context-dependent, and under conditions of NAD + depletion, specific cell types, dosing imbalances, or advanced disease, SIRT1 may exacerbate oxidative damage by impairing repair enzyme activity, exacerbating mitochondrial dysfunction, and weakening antioxidant responses

"Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice"

Position paper on behalf of AIRO (Italian Association of Radiotherapy and Clinical Oncology)

In: Human Colonic Bacteria

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