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There are real trade-offs

It is also the easiest site for self-administration since you have direct visual access and full range of motion with both hands

The gradual dose escalation approach used in trials also mirrors what we see with Wegovy and Mounjaro, helping to minimise initial side effects

Retatrutide binds it with low-nanomolar affinity (EC 50 ~0.1 nM)

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Thats because Mounjaro has a dual-action that activates GIP & GLP-1 receptors agonist, often described at dual-hormone injection