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Neuropathic pain, precipitated by lesions or pathologies of the somatosensory system, is characterized by aberrant sensations following neuroanatomical pathways, diagnosed through comprehensive physical evaluations, confirmatory testing, and instruments like the Neuropathic Pain Questionnaire and painDETECT screening tool

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Current US prescribing information lists personal or family history of medullary thyroid carcinoma (MTC), MEN 2, and previous serious hypersensitivity to tirzepatide or its ingredients as strict contraindications

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The HepG2 cell line was gifted by Xianghua Yans lab (Huazhong Agricultural University)