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A score of three or more should prompt referral, especially when features such as inflammation, oozing or bleeding, and change in sensation are present

A recent meta-analysis has subsequently confirmed a clear class effect of GLP-1RAs in reducing MACE in patients with T2D [96]

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FIGURE 1 Glutathione S -transferase P1 is also involved in cell death regulation, interacting with apoptotic signaling pathways as for example c-Jun NH2-terminal kinase (JNK1), ERK1/ERK2, or tumor necrosis factor receptor-associated factor 2 (TRAF2