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Here we ask if allosteric activation of the hepatocyte growth factor (HGF) cascade via Dihexa, a small molecule drug candidate, can protect hair cells from aminoglycoside toxicity

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163 ShangJ.DeguchiK.YamashitaT.OhtaY.ZhangH.MorimotoN.et al (2010)

With that being said, over one-third of participants in the trials did not progress to the highest dose, possibly because they could not tolerate the medication