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For example, Bacillus fragilis can activate the expression of NLRP3, and Hp can promote the activation of NLRP3 and caspase-1 and the secretion of IL-1b through TLR4, MyD88 and NF-kB [188]

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In our study, we found that the increased A plaques firstly appeared in the cortex and hippocampus of earlier 8-week ethanol exposed APP/PS1 mice (in both 2BC and IP paradigms), and no A plaque was found even after 10 weeks ethanol exposure in WT mice, suggesting that chronic ethanol exposure did not directly result in A plaques but accelerate the A deposition

Ophthalmology 128 , 561573 (2021)