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It is is caracteristized by a prolonged exhaustion state, uneasily relieved by rest and often exacerbated by physical or intellectual effort and emotions

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Taegtmeyer H, Beauloye C, Harmancey R, Hue L (2015) Comment on Nolan et al

There may be a synergistic effect of the interaction of this asthma phenotype of asthma and obesity on the increase in circulating levels of inflammatory cytokines as well as the mechanically led lung function changes