Microglia mediated neuroinflammation in autism spectrum disorder
Partial reduction reactions occur even under physiologic conditions, causing release of superoxide radical (O 2 ) and hydrogen peroxide.[] NATURAL SOURCES OF GLUTATHIONE Glutathione is available naturally in fresh leafy vegetables, broccoli, walnuts, chestnuts, oranges, whey protein, tomatoes, fresh fruits, avocados, asparagus, meat, and poultry.[] PHARMACEUTICAL FORMULATIONS OF GLUTATHIONE Glutathione is available as oral preparations (pills, sublingual tablets, solutions, syrups, and sprays) and parenteral forms (IV preparations)
Glutathione may be the mother of all antioxidants, but it does not work by itself
Craven et al., 2022
Therefore, cancer cells must fight against high level of ROS to strive for progression and develop resistance to apoptosis through antioxidant defense systems, especially at early stages (15)
23, 24, 25 In three independent case/control cohorts, children with autism were shown to exhibit abnormal plasma levels of metabolites in the pathway of glutathione redox metabolism
