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383 SIRT5-catalyzed demalonylation and inactivation of SDHA block the TCA cycle and induce succinate accumulation, promoting tumorigenesis and drug resistance

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Yet another strategy is to use a molecular degrader of extracellular proteins, which links a target-binding unit (for instance binding to IgG, as with BHV-1300 [418]) to a motif that binds asialoglycoprotein receptors (ASGPR) to direct its targets to endolysosomal degradation in the liver [419, 420]

10.3390/nu13082878 482 WuJ.LiM.LiA.JiX

These experiments demonstrate that RT reversibly reacts with GSH inside cells and can reflect intracellular GSH dynamics

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