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Previous studies have shown that oncogenic KRAS drives extensive metabolic rewiring in PDAC, including alterations in glycolytic flux 19,20 and autophagy/mitophagy, 24,37 as well as shifts in amino acid, 22 lipid 38 and cholesterol 39 metabolism

Since leaky gut occurs once this lining and barrier is compromised, this can cause a myriad of autoimmune symptoms and gut disorders such as dysbiosis

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Each time a cell divides, telomeres shorten, eventually triggering cellular senescence or apoptosis - effectively limiting the replicative lifespan of normal somatic cells to approximately 50-70 divisions (the Hayflick limit)

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