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Developing strategies to enhance secretion from intestinal L cells could therefore provide alternative therapies for a range of conditions, including Type 2 diabetes and obesity
In one study of over 83,000 patients, semaglutide was associated with a 50%-56% lower risk for both incidence and recurrence of alcohol use disorder over a 12-month follow-up compared with other anti-obesity medications
The cleavage of GIP(1-30)NH 2 subsequently results in GIP(3-30)NH 2 , a fragment that binds to the human GIP receptor with high affinity but does not have any intrinsic activation of the human GIP receptor in physiological concentrations (14)
Moreover, not all patients with MASH are overweight or obese
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