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It is based on the native GIP sequence with modifications that enable cross-reactivity at the GLP-1 receptor, plus a C20 fatty diacid chain attached via a linker for albumin binding (half-life approximately 5 days)
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for the treatment of type 2 diabetes mellitus and for weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity
Most patients report eating one-third to one-half their baseline portions at meals
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It is generally asymptomatic and tends to improve with growth
Both MT1 and MT2 receptors are widely distributed in the brain and appear to have differential functions in rapid eye movement (REM) versus non-REM sleep, anxiety, and vigilance 49,50,51,52,53
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