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Most trials were performed on obese, but otherwise healthy adults, mostly men

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The UK Summary of Product Characteristics (SmPC) for Wegovy and the British National Formulary (BNF) list no direct pharmacokinetic interactions between semaglutide and antidepressants, including SSRIs like sertraline

The PlexusDx protocols PlexusDx offers clinician-supervised compounded GLP-1 protocols in its Weight Management Protocols Semaglutide Injection, Semaglutide Oral, Tirzepatide Injection, Tirzepatide Oral, Microdose GLP-1, and GLP-Squared with pricing published per product as of April 2026