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Abnormally activated microglia and hypertrophic astrocytes around amyloid plaques in AD brains release cytotoxic molecules, such as proinflammatory cytokines and ROS, which enhance A formation and deposition and further damage neurons

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During this time, samples were kept at room temperature

Generally, after marketing approval, pharmacovigilance analysis could be conducted by utilizing the ADE data from public database such as the FAERS database

A detailed study of 55,460 non-diabetic patients revealed gastroparesis rates of 6.5 per 1000 person-years in semaglutide users

Tirzepatide is the first approved dual GIP/GLP-1 receptor agonist, engineered from the native GIP peptide backbone with structural modifications enabling potent activation of both incretin receptors