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In the absence of valine, HDAC6 accumulates in the nucleus and promotes Tet2 (ten-eleven 2) deacetylation, subsequent DNA demethylation, and genomic instability in cancer cells [159]

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Additionally, the rate at which cyanocobalamin is excreted from the body via urine is three times higher than that of methylcobalamin, and the retention of cyanocobalamin is less than twice that of hydroxocobalamin