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If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy

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Dillman et al, 2013), and thus, there might be an ongoing requirement for KAT6A for brain function, which might also benefit from treatment increasing histone acetylation levels

doi: 10.3390/antiox12020433 89 DongJHuangLKimM-YChoJY