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B cells are also central to the pathogenesis of RA, contributing to autoantibody production, inflammation, and immune dysregulation, and B cells depletion with anti-CD20 antibody significantly improve RA symptoms (Roll et al., 2006) (Figure 1)
Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, Lin X, Feng XH
10.1080/13543776.2019.1556258 259 RajaeiM.RashediH.YazdianF.Navaei-NigjehM.RahdarA.Dez-PascualA
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Talk with your doctor for advice if you believe you may benefit from vitamin B12 supplements or injections.
Research target: Nicotinamide N-methyltransferase (NNMT)
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