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Small, consistent drops are a good sign

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The smartest approach is to start with realistic expectations

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Interestingly, even heterozygous Bbs5 +/ mice, which displayed normal body composition and energy metabolism compared with WT controls (Supplemental Figure 1, KV), were resistant to leptin (Supplemental Figure 3, K, L, O, and P), suggesting that leptin resistance may serve as a potential biomarker even in individuals with a single Bbs gene mutation

8 The applicability of GLP-1RA to this additional group of patients is intriguing