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Potency: In nitrogen balance studies (Tomas et al.), LR3 was significantly more effective than native IGF-1 at promoting weight gain and nitrogen retention, even with once-daily dosing

Furthermore, folates are substrates for less-selective transport proteins like organic anion transporter OATP1B1, multidrug resistance-associated proteins (MRPs), and the breast cancer resistance protein 275,886

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Older Adults: Absorption naturally decreases with age