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Recent trials have shown: Up to 20% body weight reduction with weekly GLP-1 agonists (Wilding et al., NEJM) Improvements in HbA1c, fasting glucose, and cardiovascular outcomes (Marso et al., NEJM) This drug class is now widely used for: Obesity (with or without diabetes) Type 2 diabetes PCOS-related insulin resistance Metabolic syndrome Common Side Effects and Patient Concerns Despite their benefits, GLP-1 agonists are not without risks or drawbacks

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On April 17, Eli Lilly announced that its drug orforglipron became the first oral GLP-1 to successfully complete a Phase 3 trial for safety and efficacy for people with diabetes and obesity

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Start a fiber supplement before or at the same time you begin GLP-1 medication, not after constipation develops