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If significant fibrosis is confirmed, patients should be referred to a specialist to perform liver biopsy and confirm the diagnosis histologically (59)

Age is another factor to consider

Given its small molecular weight, -Arbutin, with its hydroxyphenyl head, can easily fit into the binding pocket of both hTYR and mTYR

It is widely recognized for its anti-aging properties, which extend to brain health

Murphy MP

doi:10.1371/journal.pone.0033944 Lederman RJ, Mendelsohn FO, Anderson RD, Saucedo JF, Tenaglia AN, Hermiller JB, Hillegass WB, Rocha-Singh K, Moon TE, Whitehouse MJ et al (2002) Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial