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BMC Gasteroenterology, 20 , 263

These included PTGS2 , an established marker of ferroptosis, SLC7A11 , which encodes one subunit of the key ferroptosis suppressor System X c , PLA2G4A , a cytosolic phospholipase A2 responsible for cleaving arachidonic acid from the membrane, and several other ferroptosis-related genes

RSL3 suppresses spheroid formation and viability, and halts migration of PTC cells in vitro We postulated that the RSL3-mediated suppression of thyroid tumor cell viability is a ferroptosis pathway-dependent process, therefore, we treated K1 cells with a lethal dose of RSL3 alone and in the presence of either a ferroptosis inhibitor Fer1, or a pan caspase inhibitor, Z-VAD-FMK (ZVAD) and measured cell viability

Breed Sci 61:310 Eshdat Y, Holland D, Faltin Z, Ben-Hayyim G (1997) Plant glutathione peroxidases

However, while strengthening research on biomarkers is essential, these discoveries can only translate into meaningful clinical benefit if accompanied by improvements in healthcare coverage that facilitate timely diagnosis, treatment, and follow-up for the broader population