Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy
Deintensification of treatment goals is recommended to reduce the risk of hypoglycemia if it can be achieved within the individualized A1C target
Serial blood samples were collected for PK analysis at pre-specified intervals up to 672 h after the final dose (pre-dose, 4, 6, 12, 24, 36, 48, 72, 120, 168, 336, and end-of-study at 672 h)
Consistent with the types of adverse events seen in clinical trials for other incretins, the most common adverse events among participants treated with retatrutide (9 mg and 12 mg, respectively) were nausea (38.1% and 43.2%) vs
Manage Side Effects: Nausea, constipation, and diarrhea are common side effects