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(2) DHODH: DHODH is a mitochondrial flavoprotein localized to the inner mitochondrial membrane, where it catalyzes the fourth and rate-limiting step of de novo pyrimidine biosynthesisthe oxidation of dihydroorotate to orotate 42,43

In Figure 10 the next phase of catalysis is reduction of the C596-C597 disulfide by disulfide exchange

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New blood vessel growth serves healing purposes, but uncontrolled angiogenesis has implications for conditions involving abnormal vascular proliferation

References 2018 The Author(s)