In rats with HFD, liver fat accumulation can be prevented by the regulation of mitochondrial dysfunction through the mechanisms adopted by LA
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Consider: Baseline blood pressure and heart rate measurement before starting combination therapy Regular monitoring during dose titration of either medication Prompt evaluation of palpitations, chest pain, or shortness of breath Caution in patients with pre-existing cardiovascular disease , including coronary artery disease, arrhythmias, or uncontrolled hypertension ECG evaluation if indicated by clinical history or symptoms Nutritional adequacy must be maintained
39 Table 2
The literature reports that GLP-1 agonists increase excessive enzyme expression and suppress reactive oxygen species (ROS) 73,74
After 4 weeks, the dose is commonly increased to 0.5 mg once weekly
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