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Furthermore, TrxR inhibition by different gold-based compounds induces ferroptosis in KRAS-WT lung cancer [103] , triple-negative breast cancer cells [104] , and hepatic cells [105]

Pyroptosis: palmitoylation regulates GSDMD activation and pore formation

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The deposition of these crystals occurs as a consequence of hyperuricemia , which can result from overproduction or underexcretion of uric acid

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For instance, they secrete anti-inflammatory cytokines such as IL-10, which suppresses T-cell activation and promotes the differentiation of regulatory T cells (Tregs), further enhancing tolerance (39, 40)