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VidalAlaball J, Butler C, CanningsJohn R, Goringe A, Hood K, McCaddon A, McDowell I, Papaioannou A

doi:10.1016/j.bcp.2019.02.008 Dimet-Wiley A, Latham CM, Brightwell CR, et al

(Scientific Reports, 2024) showed that 5-Amino-1MQ improves grip strength by 40% in aged mice, surpassing exercise alone (by 20%)

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This synergistic effect arises because a lowcalorie diet reduces fat intake, while it promotes lipolysis and energy expenditure, together achieving more efficient fat reduction and metabolic improvement

Research with NNMT blockers such as 5-amino-1MQ has demonstrated increased GLUT4 expression, greater glucose utilization, and enhanced metabolic activity