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There is evidence that iron accumulation or deficiency can alter adipose tissue microenvironment and secretion of IR-related adipokines (leptin and adiponectin), and lead to reduced glucose transport after insulin stimulation (Huang et al., 2011)

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243 Furthermore, energy-boosting pathways, including the AMPK and SIRT pathways, enhance FAO and glycolysis, increasing heat generation beyond ATP production under the influence of UCP1

A study conducted on pregnant mice, the species with a very similar biological and behavioral makeup to humans, also found that B12 deficiency led to high cholesterol levels and a significant increase in body fat percentage in pregnant mice

(PubMed) Ueland T, Svardal A, Oie E, et al

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