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GLP-1 & GIP weight loss medications functions by targeting two key receptors in the body: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

Some studies suggest that the beneficial effects of GLP-1RAs can be dampened by the deleterious effects of long-standing T2DM resulting in the reduced capacity to secrete insulin and diminished incretin effects, resulting in reduced glucose-lowering efficacy of GLP-1RA [89, 90]

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mNSS, modified neurological severity score

Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort