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434 Over time, this selective pressure enriches resistant CSC clones, leading to tumor recurrence and therapy failure

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Electrophysiological dysfunction is also discussed here and include ion channel dysfunction (acetylcholine channels [82,83,84] and transient receptor potential ion channels [62, 63, 85,86,87]), and electrical changes to osmotic challenge [1]

Hence, antioxidant augmentation could be a promising approach to maintain the microenvironment equilibrium

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