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The specific BUD will be listed on the prescription label, and the medication should remain safe and effective until that date if properly stored

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They also impact the brain, particularly the hypothalamus, the area that controls hunger, by activating appetite-suppressing neurons, she says

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Curr Med Res Opin 2008;24:294352.ArticlePubMed 31

Decision factors: Weight loss goals: Want maximum weight loss and can tolerate side effects: Tirzepatide (Zepbound) shows ~4% greater weight loss than semaglutide on average Want proven cardiovascular benefits: Semaglutide has demonstrated 20% reduction in major cardiovascular events in the SELECT trial Want to try oral option: Oral semaglutide (Rybelsus) for diabetes, though weight loss is less than injectable Side effect sensitivity: Some people tolerate one better than the other