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Additionally, the combined polymorphisms in PNPLA3 and SAMM50specifically four SNPshave been linked to an increased risk of MASLD and elevated serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) levels, suggesting more severe hepatic injury (109)

doi: 10.1038/nrrheum.2011.115

Perturbation of Sphingolipid Metabolism and Ceramide Production in HIV-Dementia

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