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Numerous studies have confirmed that geniposide, the main pharmacological component of Gardenia jasminoides , can target different mechanisms of NAFLD, indicating its great potential for the treatment of liver diseases (Figure 2)

However, for a trans -inhibition interaction model, there would be no requirement for each domain to be linked (87), therefore perhaps this interface with the largest buried surface area may have some biological relevance

Upon receptor engagement in pituitary somatotroph cells, Hexarelin has been studied for its activation of intracellular calcium signaling and downstream growth hormone release mechanisms, offering researchers a tool for investigating GH secretion pathways independent of GHRH-driven models

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