Beyond the absolute contraindications, several situations call for heightened caution in the class framing and are firmly a clinicians domain: a history of pancreatitis or symptomatic gallstones, significant gastrointestinal motility disorders (such as gastroparesis, which slowed gastric emptying can worsen), diabetic retinopathy that is not stabilized, severe renal impairment where dehydration from GI side effects raises risk, and any concurrent use of insulin or a sulfonylurea, where the additive glucose-lowering can produce hypoglycemia
Private label and contract manufacturers are increasingly attracting M&A attention and with the rise of GLP-1s, they stand to benefit from additional buyer interest
Game developer Pocket Gems, which took in an estimated $34 million in 2015 from Episode, a choose-your-own-adventure game targeted at teenage girls, released a chapter of the game with singer Demi Lovato dubbed Demi Lovato: Path to Fame
Retrieved March 10, 2026, from The four states that removed coverage of GLP-1 AOMs for weight loss collectively spent approximately $2.5 billion on Wegovy, Zepbound, and Saxenda in a 30-month span, on a gross basis for all indications
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