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Dose increases are typically spaced four weeks apart

Studies show that many people regain weight within months of discontinuing GLP-1 medications

This dosing regimen produced measurable senescent cell clearance and functional improvements including enhanced physical activity, improved kidney function markers, and restored fur quality

But, in patients without diabetes, preliminary studies suggest GLP-1 use could be associated with lower risk, although more research is needed 32

Initial studies comparing tirzepatide vs retatrutide indicate that retatrutide is associated with gastrointestinal discomfort and has shown a somewhat increased occurrence of these side effects

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