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Factors such as side effect profiles, coexisting medical conditions, access, and cost must be considered

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Participants were divided into four groups based on the PA levels as previously described [14, 29], including inactive (with no moderate- or vigorous-intensity PA), insufficiently active (with total MET being 0 to 600 METs-min), moderate active (total METs being 600 to 3000), and highly active (total METs more than 3000)

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Regarding the underlying mechanism, IR in the brain significantly contributes to neurodegenerative processes, and GLP-1RAs modulate downstream signaling pathways, including mitochondrial biogenesis, autophagy, inflammation, and cell survival

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