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Silymarin, a mixture of several related polyphenolic compounds from milk thistle (Abenavoli 2010), promotes detoxification by several complementary mechanisms

Puliga E, Min Q, Tao J, Zhang R, Pradhan-Sundd T, Poddar M, et al

Much of the current evidence on humans comes from large observational studies using health record data rather than randomized clinical trials

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Within the brain ethanol-derived acetate has been found to directly bind to neuronal chromatin where it is converted to acetyl-CoA via chromatin-bound acetyl-CoA synthetase 2 (ACSS2)

Limit alcohol intake, avoid doubling a missed dose, and refrain from driving if dizziness or weakness occurs